[SFC바이오-관절 프로젝트] 논문 01. Anti-Arthritic Activities of Supercritical Ca…
페이지 정보
작성자 최고관리자 댓글 0건 조회 264회 작성일 20-12-14 15:33본문
1) 저널명 : Nutrients. 2019
2) 논문명 : Anti-Arthritic Activities of Supercritical Carbon Dioxide Extract Derived from Radiation Mutant Perilla Frutescens Var. Crispa in Collagen Antibody-Induced Arthritis
3) 요약
We investigated the anti-arthritic eects of the radiation mutant Perilla frutescens var. crispa leaf extract (SFE-M) and wild type leaf extract (SFE-W), both prepared by supercritical carbon dioxide
(SC-CO2) extraction, on collagen antibody-induced arthritis (CAIA) in Balb/c mice. Animals were randomly divided into four groups: control, CAIA, CAIA + SFE-M (100 mg/kg/day), and CAIA + SFE-W (100 mg/kg/day).
The mice were subjected to the respective treatments via oral gavage once daily for 4 days. Mice treated with SFE-M developed less severe arthritis than the CAIA mice.
They showed significantly improved arthritic score, paw volume, and paw thickness compared to the CAIA mice from days 3 through 7.
Furthermore, histopathological analysis of ankle for inflammation showed that SFE-M treatment reduced inflammatory cell infiltration and edema formation.
Similarly, the neutrophil-to-lymphocyte ratio (NLR) in the whole blood was 37% lower in mice treated with SFE-M compared with the CAIA mice.
However, treatment with SFE-W did not result in any significant dierence compared with the CAIA group.
In conclusion, SFE-M treatment delays the onset of arthritis and alleviates its clinical manifestations in CAIA mice.
2) 논문명 : Anti-Arthritic Activities of Supercritical Carbon Dioxide Extract Derived from Radiation Mutant Perilla Frutescens Var. Crispa in Collagen Antibody-Induced Arthritis
3) 요약
We investigated the anti-arthritic eects of the radiation mutant Perilla frutescens var. crispa leaf extract (SFE-M) and wild type leaf extract (SFE-W), both prepared by supercritical carbon dioxide
(SC-CO2) extraction, on collagen antibody-induced arthritis (CAIA) in Balb/c mice. Animals were randomly divided into four groups: control, CAIA, CAIA + SFE-M (100 mg/kg/day), and CAIA + SFE-W (100 mg/kg/day).
The mice were subjected to the respective treatments via oral gavage once daily for 4 days. Mice treated with SFE-M developed less severe arthritis than the CAIA mice.
They showed significantly improved arthritic score, paw volume, and paw thickness compared to the CAIA mice from days 3 through 7.
Furthermore, histopathological analysis of ankle for inflammation showed that SFE-M treatment reduced inflammatory cell infiltration and edema formation.
Similarly, the neutrophil-to-lymphocyte ratio (NLR) in the whole blood was 37% lower in mice treated with SFE-M compared with the CAIA mice.
However, treatment with SFE-W did not result in any significant dierence compared with the CAIA group.
In conclusion, SFE-M treatment delays the onset of arthritis and alleviates its clinical manifestations in CAIA mice.
첨부파일
- Anti-Arthritic Activities of Supercritical Carbon Dioxide Extract Derived from Radiation Mutant Perilla Frutescens Var. Crispa in Collagen Antibody-Induced Arthritis.pdf (2.4M) 3회 다운로드 | DATE : 2020-12-14 16:49:30
- 이전글[SFC바이오-관절 프로젝트] 논문 02. A New Monoterpene from the Leaves of a Radiation Mutant Cultivar of Perilla frutescens var. crispa with Inhibitory Activity on LPS-Induced NO Production 20.12.14
- 다음글[SFC바이오-알츠하이머 프로젝트] 논문 02. Effect of natural antioxidants on the aggregation and disaggregation of beta-amyloid 20.12.14
댓글목록
등록된 댓글이 없습니다.