[SFC바이오-관절 프로젝트] 논문 02. A New Monoterpene from the Leaves of a Radiation Mutant Cultivar of Perilla frutescens var. crispa with Inhibitory Activity on LPS-Induced NO Production > 자료실

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[SFC바이오-관절 프로젝트] 논문 02. A New Monoterpene from the Leaves of a Radiat…

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작성자 최고관리자 댓글 0건 조회 343회 작성일 20-12-14 15:33

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1) 저널명 : Molecules, 2017

2) 논문명 : A New Monoterpene from the Leaves of a Radiation Mutant Cultivar of Perilla frutescens var. crispa with Inhibitory Activity on LPS-Induced NO Production

3) 요약
    The leaves of Perilla frutescens var. crispa (Lamiaceae)—known as ‘Jureum-soyeop’ or ‘Cha-jo-ki’ in Korean, ‘ZI SU YE’ in Chinese, and ‘Shiso’ in Japan—has been used as a medicinal herb.
    Recent gamma irradiated mutation breeding on P. frutescens var. crispa in our research group resulted in the development of a new perilla cultivar,
    P. frutescens var. crispa(cv. Antisperill; PFCA), which has a higher content of isoegomaketone.
    The leaves of PFCA were extracted by supercritical carbon dioxide (SC-CO2) extraction, and phytochemical investigation on this extract led to the isolation and identification of a new compound,
    9-hydroxy-isoegomaketone[(2E)-1-(3-furanyl)-4-hydroxy-4-methyl-2-penten-1-one; 1]. Compound 1 exhibited inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.
    7 cells with an IC50 value of 14.4 M. The compounds in the SC-CO2 extracts of the radiation mutant cultivar and the original plant were quantified by high-performance liquid chromatography
    with diode array detection.

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