• 목록

1) 저널명 : International Journal of Molecular Science (IF 4.18)

2) 논문명 : Inhibitory Effects of b-Caryophyllene on Helicobacter pylori Infection In Vitro and In Vivo

3) 요약
The human specific bacterial pathogen Helicobacter pylori (H. pylori) is associated with severe gastric diseases, including gastric cancer.
Recently, the increasing resistance makes the usage of antibiotics less eectively.
Therefore, development of a new antimicrobial agent is required to control H. pylori infection.
In the current study, the inhibitory eect of -caryophyllene on H. pylori growth, as well as the antibacterial therapeutic eect, has been demonstrated.
b-caryophyllene inhibited H. pylori growth via the downregulation of dnaE, dnaN, holB, and gyrA and also downregulated virulence factors such as CagA, VacA, and SecA proteins.
b-caryophyllene inhibited expression of several T4SS components, so that CagA translocation into H.
pylori-infected AGS gastric cancer cells was decreased by b-caryophyllene treatment.
b-caryophyllene also inhibited VacA entry through the downregulation of T5aSS.
After -caryophyllene administration on Mongolian gerbils, the immunohistochemistry (IHC) and Hematoxylin&Eosin stains showed therapeutic eects in the treated groups.
Hematological data, which was consistent with histological data, support the therapeutic eect of -caryophyllene administration.
Such a positive effect of -caryophyllene on H. pylori infection potently substantiates the natural compound as being capable of being used as a new antimicrobial agent or functional health food
to help patients who are suffering from gastroduodenal diseases due to H. pylori infection.