• 목록

1) 저널명 : Nutrients ( IF 4.17)

2) 논문명 : Effect of b-caryophyllene from cloves extract on Helicobacter pylori eradication in mouse model

3) 요약
New antibacterial treatments against Helicobacter pylori are needed as H. pylori is acquiring antibiotic resistance.
b-caryophyllene is a natural bicyclic sesquiterpene, with anti-inflammatory and antimicrobial effects.
This study investigates the eects of H-002119-00-001 from -caryophyllene on the eradication of H. pylori in a mouse model, and its eects on the inflammation of the gastric mucosa.
To evaluate the anti-H.pylori ecacy of -caryophyllene, a total of 160 mice were divided into eight groups (n = 10 each) and were administered dierent treatments for 2 and 4 weeks.
H. pylori eradication was assessed using a Campylobacter-like organism (CLO) test and H. pylori qPCR of the gastric mucosa.
The levels of inflammation of gastric mucosa were assessed using histology and immunostaining.
H-002119-00-001 decreased bacterial burden in vitro.
When H-002119-00-001 was administered to mice once daily for 2 weeks, cure rates shown by the CLO test were 40.0%, 60.0%, and 70.0% in groups 6, 7, and 8, respectively.
H. pylori levels in gastric mucosa decreased dose-dependently after H-002119-00-001 treatment.
H-002119-00-001 also reduced levels of inflammation in gastric mucosa.
H-002119-00-001 improved inflammation and decreased bacterial burden in H. pylori-infected mouse models.
H-002119-00-001 is a promising and eective therapeutic agent for the treatment of H. pylori infection.